Ex-AFL player Paul Seedsman has had more hands on his head than he can recall.
After suffering a head knock that ended his career four years ago and left him with debilitating migraines, insomnia and memory loss, the former Crows midfielder has sought treatments that have ranged from the traditional to the eccentric.
βOne guy did a lot of clicking, he was trying to clear all these things from my head, almost like a spiritual sort of thing. So I did that,β Seedsman said.
βExtreme massage, pressure point relief, things like craniosacral [therapy] … Iβve had acupuncture all over. Iβve tried a lot of different medications, supplements … Iβm open to most things these days.β
When the 34-year-old heard of a new clinical trial in the works at Monash University involving psychedelics, he had no hesitation in putting his hand up to be considered.
While Seedsman now lives in South Australia, he is contemplating coming to Victoria, where he is originally from, and staying with a relative for the duration of the trial so he can participate.
βI have a wife and kids … and Iβve got things that I want to do in life that just are on hold at the moment β¦ so if thereβs something that can help me, Iβd absolutely love that,β he said.
βBut also, if I can be a part of something in any way, shape or form to help people, the next generations, not have to go through this, then Iβm really keen.β
Researchers are exploring whether psilocybin β the psychedelic compound found in magic mushrooms β could hold the key to helping people like Seedsman recover from the long-term effects of concussion, also known as mild traumatic brain injury.
Someone is hospitalised for concussion roughly every 18 minutes in Australia, based on 2021-22 health data, and as many as one in two sufferers experience persistent symptoms.
Currently, there are no clinically proven effective treatments. But Monash is hopeful it can change that after a pre-clinical trial found trauma-affected rats that were given a single dose of psilocybin showed evidence of recovery inside the brain and behaviourally.
The university has just received approval for the trial, and a $1.5 million federal grant to see whether similar results can be achieved in humans.
It is now calling for about 60 people who have experienced post-concussion symptoms for at least six months to take part in a first-of-its-kind randomised double-blind clinical trial of psilocybin-assisted therapy.
After completing an eligibility survey and going through the screening process, approved candidates will be guided through a six-week course, involving just a single dose of psilocybin, followed by therapy and self-guided exercises.
Dr Paul Liknaitzky, who heads up Monash Universityβs Clinical Psychedelic Lab, said the drug had two useful qualities that had been proven in other cases β its capacity to treat psychiatric conditions like depression and anxiety, and its ability to increase brain plasticity for several weeks, enabling enhanced learning and behaviour change.
If successful, Liknaitzky said, the trial would be expanded to other states, though he stressed the research was still in its early stages, and it was important not to be over-confident.
While prescriptions for psychedelics are on the rise in Australia, some experts have raised concerns about the inability to control for the placebo effect in clinical trials due to the fact people usually know if they have taken the drug. Monash is planning for this by giving participants different strengths β either a high micro-dose of five milligrams, or a standard macro-dose of 25 milligrams.
The trial comes as global discussion on concussion grows, thanks in large part to the public battles of athletes like Seedsman and some former players taking the leagues and clubs for which they played to court.
And as demand for a solution has grown, so, too, has the interest from private pharmaceutical companies and investors.
Neurologist Professor Terence OβBrien, the lead researcher for the Monash University trial, said this made legitimate research all the more important.
βThereβs lots of people waving around saying, βWeβve got the magic treatmentβ, and theyβll trot out a whole bunch of patients who say, βYeah, we took this treatment and I feel so much better nowβ β¦ but thereβs just not the evidence base,β he said.
OβBrien said any publicly available treatment worth its salt should have gone through double-blind randomised controlled trials at a large enough scale, and have peer-reviewed research and Therapeutic Goods Administration approvals.
He said it was also important to remember prevention was always better than treatment.
While Paul Seedsman would love to go back in time and avoid the head knock that led him here, he said he was trying to move forward.
βI took it for granted β¦ having a brain that just worked,β he said.
βNow any time Iβm headache-free, Iβm like, βOh God, how good does this feel?β You know, it doesnβt last very long, but those moments are nice.
βIβve just got to try and stay positive … For a long period of time, I was feeling like I was just sort of existing, where 1781498561 I want to get back to living.β
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Bridget McArthur is a sports affairs reporter at The Age, covering the intersection of sports and politics/business/economy/society.Connect via X or email.